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Herpes amplicon vectors used to develop vaccines against metastatic liver cancer.
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Vaccines consisting of irradiated colon cancer cells that released granulocyte-macrophage colony-stimulating factor (GM-CSF), or GM-CSF along with the chemokine RANTES and the co-stimulatory molecule B7-1, were effective against metastatic hepatic cancer in mice, according to researchers in the U.S.
Keith A. Delman and colleagues at Memorial Sloan-Kettering Cancer Center in New York City irradiated CT-26 colorectal cancer cells and then exposed them for 20 minutes to herpes amplicon vectors to transfect the cells with genes for RANTES, B7-1, or GM-CSF.
Two vaccines were prepared from the engineered cancer cells and were used to vaccinate BALB/c mice with colorectal cancer. One vaccine incorporated cells that secreted only GM-CSF and the other was formulated with cells that released all three molecules. Vaccination was done with and without 60% hepatectomy.
Both vaccines exhibited antitumor effects. Without hepatectomy, efficacy of the vaccines was similar. However, after hepatectomy, the multiagent vaccine was significantly more effective than the single-agent vaccine (50% vs. 12.5%, respectively; p=0.03) (Efficacy of multiagent herpes simples virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Annals of Surgery, 2002;236(3):337-343).
Mean nodule count in animals treated with the single-agent vaccine was 40 compared with 232 for the untreated controls (p
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Source: HighBeam Research, Herpes amplicon vectors used to develop vaccines against metastatic...