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Caspase-8, which is known to help trigger apoptosis, also helps activate many immune system cells to fight infection, researchers discovered.
The enzyme may be deficient in some people, perhaps explaining vaccine or immune system failures, and thus it may be a target for a new class of anti-inflammatory or immunosuppressive therapies, said Dr. Michael Lenardo and his colleagues at the National Institute of Allergy and Infectious Diseases, Bethesda, Md.
The investigators discovered this second ...