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Melanomas shrink 50% with adoptive transfer. (Response Seen in 6 of 13 Patients).
A novel two-step process called adoptive transfer resulted in more than 50% tumor shrinkage in 6 of 13 patients with malignant melanoma, said Dr. Stephen A. Rosenberg of the National Cancer Institute in Bethesda, Md.
In the adoptive transfer technique, investigators used a small fragment of a patient's melanoma to grow the patient's own T cells in vitro (Science, 19 September 2002 [10.1126/science.1076514]).
This method produced "staggeringly high numbers of immune cells," Dr. Rosenberg said at an American Medical Association--sponsored conference. "Nothing like this has been approached in a human before," he said. T cells were then exposed to the tumor, activating them to recognize and attack tumor cells in the body.
The patients first received chemotherapy to deplete their ...