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Aggressive ovarian cancer linked to overexpression of five genes. (Quest to Develop Multimodal Screen).
ORLANDO, FLA.--Overexpression of five genes on chromosome 19 is associated with tumor growth, aggressiveness, and metastasis of ovarian cancer and may prove useful for clinical diagnosis and management, preliminary research suggests.
"We are trying to develop a multimodal screen for ovarian cancer," Dr. George Yousef said at the annual meeting of the American Association for Clinical Chemistry. Like many cancers, multiple genetic effects spur ovarian cancer, and a clinical test for early detection or disease progression would include a panel of genetic markers.
Dr. Yousef and his associates at the University of Toronto identified 15 genes that program for proteins involved in various disease states, including cancer. These proteins are called kallikreins and are present in the bloodstream, making them suitable for clinical detection. A well-known example of a kallikrein is PSA (hK3), which is ...