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Regulatory T cells may have a role in poor immune response against tumor antigens.
2002 NOV 27 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The weak immunogenicity of tumor antigens may be due to regulatory T cells that suppress the response of self-reactive T cells to prevent development of autoimmune disease, according to a report in the Journal of Immunology.
"In mice, depletion of regulatory T cells by antibody therapy leads to more efficient tumor rejection," said Udaya K. Liyanage and colleagues at the Alvin J. Siteman Cancer Center in St. Louis. "Regulatory T cell-medicated suppression of antitumor immune responses may partly explain the poor clinical response to vaccine-based immunotherapy for human cancer."
The investigators determined levels of CD4- and CD25-expressing regulatory T cells (T[subscript]reg) in the peripheral blood lymphocytes (PBL), tumor-infiltrating lymphocytes, and local lymph node lymphocytes in 35 breast cancer patients, 30 pancreas cancer patients, and 35 healthy control subjects.
Significantly higher levels of T[subscript]reg as a percentage of the total CD4+ cell population were found in the breast cancer (16.6%, p
The T[subscript]reg secreted transforming growth factor beta (TGF-beta) and interleukin-10 (IL-10), but did not release interferon-gamma (IFN-gamma). When cells that normally do secrete IFN-gamma, such as activated CD8+ or CD4+25- cells, were exposed to T[subscript]reg, cell proliferation and IFN-gamma release was disrupted.
"We conclude that the prevalence of T[subscript]reg is increased in the peripheral blood as well as ...
- Siteman Cancer Center Adds Second TomoTherapy[R] HioArt[R] Treatment System.
- Press release article from: Business Wire January 7, 2009 700+ words
...announced today that the Siteman Cancer Center at Barnes-Jewish Hospital...Medicine and medical director of Siteman Cancer Center at Barnes-Jewish West County...to breast cancer cases, Siteman Cancer Center staff has applied TomoTherapy...
- Cancer Center Construction.(Siteman Cancer Center, Barnes-Jewish St. Peters...
- Magazine article from: Construction Digest May 9, 2005 700+ words
Staff St. Peters, Mo.- Construction is moving forward on the $7-million Siteman Cancer Center at Barnes-Jewish St. Peters Hospital in St. Peters. The center, scheduled to open in fall 2005, will provide outpatient...
- Physicians at Siteman Cancer Center Treat Inoperable Lung Cancer With...
- Press release article from: PR Newswire May 2, 2007 700+ words
...Her medical team at the Siteman Cancer Center at Barnes-Jewish Hospital...The medical team at the Siteman Cancer Center delivered the advanced treatment...Radiation oncologists at the Siteman Cancer Center are also using their Trilogy...
- NCCN Adds 20th Member; Siteman Cancer Center at Barnes-Jewish Hospital and...
- Press release article from: Business Wire March 21, 2006 700+ words
...member institution--the Siteman Cancer Center at Barnes-Jewish Hospital...can live better lives. The Siteman Cancer Center has multidisciplinary programs...treated there each year. The Siteman Cancer Center is a partnership with two...
- Siteman Cancer Center will expand to St. Peters.
- Newspaper article from: St. Louis Post-Dispatch (St. Louis, Missouri) (via Knight-Ridder/Tribune Business News) January 28, 2005 700+ words
...Byline: Judith VandeWater Jan. 28--The Alvin J. Siteman Cancer Center will reach into St. Charles County in the fall...staff oncologist and radiation oncologist. The Siteman Cancer Center combines the cancer care and research resources...
- New life sciences study results from Siteman Cancer Center, Department of...
- Newspaper article from: Cancer Weekly September 29, 2009 700+ words
...expression," wrote S.N. Brady and colleagues, Siteman Cancer Center, Department of Internal Medicine. The researchers...additional information, contact S.N. Brady, Siteman Cancer Center, Division of Molecular Oncology, Dept. of Internal...
- Center for Advanced Medicine/Siteman Cancer Center, St. Louis; Honorable...
- Magazine article from: Modern Healthcare October 7, 2002 700+ words
...pathways of the 14-story facility are organized around a huge skylighted atrium. Clinics housed in the building include a cancer center on the 11th floor; an eye center and radiology department on the sixth floor; and surgery center on the fourth floor...
- St. Louis cancer center achieves highest designation.
- Newspaper article from: St. Louis Post-Dispatch (St. Louis, Missouri) (via Knight-Ridder/Tribune Business News) January 4, 2005 700+ words
...Vandewater Jan. 4--The Alvin J. Siteman Cancer Center has achieved the National Cancer...science is the backbone of a cancer center," Eberlein said. "You are...Community Advisory Board. Siteman Cancer Center has been involved with a number...