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Postexposure hepatitis B vaccine not effective in hemodialysis patients.

Vaccine Weekly

| November 27, 2002 | COPYRIGHT 2002 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2002 NOV 27 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Accelerated hepatitis B vaccine schedules are not very effective for protecting hemodialysis patients after they have been exposed to hepatitis B virus (HBV).

Blood dialysis presents a significant risk for viral hepatitis transmission. According to a report in Nephrology, Dialysis, and Transplantation, doctors in the United Kingdom frequently advise preventative or postexposure accelerated HBV vaccination schedules for people at risk for infection. However, the authors of a new observational study have advised that accelerated postexposure hepatitis B vaccination does not appear to offer sufficient antiviral protection to individuals on hemodialysis.

The 105 patients included in the study were all exposed to HBV during hemodialysis. Doctors administered HBV vaccine at baseline and at months 1 and 2 thereafter, followed by a booster dose at month 12. Eighty-six patients were able to complete the full vaccination schedule.

Follow-up testing of the patients' sera 6 weeks after the last doses were given suggested a response rate of 73%, reported Kevin S. Eardley and colleagues, Birmingham Heartlands and Solihull NHS Trust, Birmingham, U.K.

"Non-European patients responded better to primary vaccination than Europeans (p=0.014)," researchers commented.

Steroids also seemed to have a negative effect on vaccine effectiveness in hemodialysis patients, while other factors such as erythropoietin dose, diabetes mellitus, or being infected with hepatitis C virus (HCV) did not.

Two years after the initial vaccines were administered, 77 patients ...

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