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DBC2 gene missing or inactive in 60% of breast cancers examined.(tumor suppressor gene)(Brief Article)
2002 NOV 21 - (NewsRx.com & NewsRx.net) -- Scientists at Cold Spring Harbor Laboratory and the University of Washington have discovered a new tumor suppressor gene that is missing or inactive in as many as 60% of breast cancers, and is also altered in lung cancer.
The discovery of the gene, called DBC2 (for deleted in breast cancer) is highly significant because DBC2 is among the first tumor suppressor genes to be clearly associated with sporadic breast cancer. Sporadic disease accounts for more than 90% of all forms of breast and other cancers, in contrast to heritable forms of cancer, which account for a relatively small percentage of the disease.
Importantly, the researchers showed that production of the Dbc2 protein in breast cancer cells kills the cancer cells or stops them ...
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Source: HighBeam Research, DBC2 gene missing or inactive in 60% of breast cancers...