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Review article covers details involved in developing effective influenza vaccines.
2002 NOV 20 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The effectiveness of an influenza vaccine prior to the season is difficult to predict because of uncertainty about circulating virus levels, vaccine strain match, and vaccine coverage, according to researchers in Italy.
Tom Jefferson at Health Reviews, Ltd., in Rome and colleagues in Italy reviewed the process of developing influenza vaccines and the factors important to their success. They begin by explaining that influenza vaccines consist of whole or partial inactivated viruses that are delivered to the patient parenterally or intranasally. Because the virus undergoes antigenic shifts and drifts, vaccine development involves matching the current circulating virus antigenic make-up.
The authors report that vaccines formulated to match yearly World Health Organization (WHO) criteria are 72% efficacious at preventing infection caused by influenza viruses A and B. However, their ability to prevent influenza-like illness (ILI) is much lower, only 37% (Influenza vaccines in adults. Occupational Medicine - Oxford, 2002;52(5):255-258).
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Source: HighBeam Research, Review article covers details involved in developing effective...