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Interaction of novel DNA structures and immune system activation studied.
2002 NOV 13 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HYBN.OB) announced the publication of two articles presenting the results of murine cell culture experiments conducted by Hybridon involving the relationships between novel DNA structures and activation of the immune system.
The articles, recently published in the Journal of Medicinal Chemistry and in Bioconjugate Chemistry, provide insights into designing potent immunomodulatory oligonucleotides (IMOs) for specific immunotherapeutic applications, the company says.
"Just as we converted antisense into promising drug candidates with our second-generation antisense technology platform now being used by an increasing number of companies, we are working to turn the first-generation CpG DNA into specific and potent immunotherapeutic agents by incorporating appropriate chemical modifications," said Sudhir Agrawal, D. Phil, Hybridon. "The murine cell culture experiments reported are just a few examples of the on-going effort at Hybridon to develop a thorough understanding of the structure/activity relationships and to create an inventory of proprietary immunomodulatory oligonucleotide compounds to effectively treat patients."
The publication in the Journal of Medicinal Chemistry (Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: Role of ...
- Coley Pharmaceutical Group Announces Positive Results from Ongoing Phase I...
- Press release article from: PR Newswire December 10, 2001 700+ words
WELLESLEY, Mass., and LANGENFELD, Germany -- Coley Pharmaceutical Group today announced Phase I study results of the company's lead product for cancer treatment. Investigators described data on CpG 7909, an immunostimulatory oligonucleotide tested in patients with relapsed or refractory
- Hybridon Identifies Additional Relationships Between Novel CPG DNA Structures...
- Press release article from: PR Newswire October 3, 2002 700+ words
...compared to the parent CpG DNA. In this study, the increase in immunostimulatory activity resulted from the...introduced in the CpG DNA. The Bioconjugate...the 5'-End of CpG DNA Affects Immunostimulatory Activity", reports that...
- Hybridon Describes Enhanced Immunomodulatory Activity of Proprietary...
- Press release article from: PR Newswire November 18, 2002 700+ words
...that linking CpG DNA through the...abrogates immunostimulatory activity, and that...increases immunostimulatory activity, also as...basis for CpG DNA recognition...ends over CpG DNA molecules...differences in immunostimulatory activity of 3...
- CpG DNA induces refractoriness in RAW264.7 cells.
- Newspaper article from: Immunotherapy Weekly March 12, 2003 700+ words
...not been known whether previous exposure to CpG DNA induces a similar suppressive response to subsequent stimulation with CpG DNA. "In the present study, we demonstrate that pretreatment with CpG DNA induces suppression of cytokine release in...
- Preclinical data show short CpG DNA immunomers elicit potent effect.
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...publication of data showing that short CpG DNA immunomers containing two sequences...sequence motif generally found essential for CpG DNA stimulation, and surprisingly act in...nude mice. The immunomodulatory use of CpG DNA is being explored broadly in anti-tumor...
- Hybridon Reports Preclinical Data Showing Short CpG DNA Immunomers Elicit...
- Press release article from: PR Newswire January 31, 2003 700+ words
...publication of data showing that in short CpG DNA immunomers containing two sequences...sequence motif generally found essential for CpG DNA stimulation, and surprisingly act in...nude mice. The immunomodulatory use of CpG DNA is being explored broadly in anti-tumor...
- CpG DNA redirects class-switching towards Th1-like Ig isotype production.
- Newspaper article from: Health & Medicine Week July 12, 2004 700+ words
...NewsRx.com & NewsRx.net) -- CpG DNA redirects class-switching towards Th1...according to the report. "Thus, CpG DNA redirects Ig isotype production by regulating...in the European Journal of Immunology (CpG DNA redirects class-switching towards...
- CpG ImmunoPharmaceuticals Raises $6.3 Million in Venture Financing Round;...
- Press release article from: PR Newswire September 19, 1997 700+ words
...old start-up company in utilizing CpG DNA motifs to enhance immune responses to...of Iowa, Dr. Krieg demonstrated that CpG DNA promotes a strong type of immune response...both of CpG ImmunoPharmaceuticals, cpg.dna@mci2000.com; or Ernie Knewitz, media...
Source: HighBeam Research, Interaction of novel DNA structures and immune system activation...