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Fellowship funds study of dendritic cell role in immune response.
2002 NOV 13 - (NewsRx.com & NewsRx.net) -- The American Foundation for AIDS Research (amfAR) has awarded Emory microbiologist Sang-Moo Kang, PhD, a fellowship to study how dendritic cells might be used to improve the immune response against AIDS.
Kang theorizes that by increasing the number of dendritic cells, which play an important role in priming immune responses and establishing immune memory, he can enhance the immune response to HIV. The findings also could prove useful in developing an effective AIDS vaccine.
Dendritic cells have a potent ability to capture foreign substances such as bacteria and viruses and present the captured substances to naive cells, thus inducing primary immune responses and establishing immune memory. After capturing foreign invaders in the skin and mucosal tissues, the dendritic cells migrate to the spleen or lymph nodes, where they stimulate immune-inducing cells.
Kang plans to anchor a dendritic-cell growth factor in the laboratory to HIV virus-like particles (VLPs), which consist of the main components of the HIV virus but not its genetic material. He then will immunize ...
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Source: HighBeam Research, Fellowship funds study of dendritic cell role in immune response.