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DTaP vaccine rarely causes serious injection site reactions.
2002 NOV 13 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A 4-year survey of medically attended injection site reactions (ISR) from the diphtheria-tetanus toxoid-acellular pertussis (DTaP) vaccine revealed that reactions were relatively uncommon.
"Since 1997, diphtheria-tetanus toxoids-acellular pertussis (DTaP) vaccines have been recommended for the five dose pertussis vaccination series," commented Lisa A. Jackson and colleagues at the University of Washington in Seattle. "To assess rates of medically attended injection site reactions (ISRs), seizures, allergic responses and febrile episodes after Tripedia DTaP vaccine administered in the context of routine care, we conducted a retrospective assessment among the population of Group Health Cooperative from 1997 through 2000."
The investigators examined the medical records relating to 76,133 doses of DTaP vaccine and found 26 cases of medically attended ISR. Six of the reactions occurred after the fourth dose of the vaccine and the other 18 occurred after the fifth dose resulting in reaction rates of 1 per 2779 and 1 per 900 immunizations, respectively. The entire upper arm was involved in 4 of the 26 ISR cases.
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Source: HighBeam Research, DTaP vaccine rarely causes serious injection site reactions.