AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Novel mucosal adjuvant safe, effective.
2002 NOV 13 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Japan and the United States have developed a chimeric protein that may offer protection from a number of bacterial toxins.
Mi-Na Kweon and colleagues at Osaka University in Osaka, Protein Express and Higeta Shoyu Co. Ltd. in Chiba, and other institutions in Chiba, Tokyo, and Birmingham, Alabama, described their "novel nontoxic form of chimeric mucosal adjuvant that combines the A subunit of mutant cholera toxin E112K with the pentameric B subunit of heat-labile enterotoxin from enterotoxigenic Escherichia coli" (mCTA/LTB) in the November edition of the Journal of Infectious Diseases.
This construct helped protect animals from the effects of tetanus toxin and influenza infection, Kweon and coauthors reported.
The researchers used a murine model to evaluate the efficacy of mucosal mCTA/LTB administration. The Brevibacillus choshinensis expression system was used to develop this protein adjuvant, they noted.
Mice who received nasal immunization with mCTA/LTB and tetanus toxoid (TT) demonstrated potent and TT-specific mucosal immunoglobulin A (IgA) responses, in addition to significant and specific IgA and IgG serum activity, study data showed. Antibody activity triggered by immunization protected mice from otherwise lethal exposure to tetanus toxin. However, mCTA/LTB failed to induce relevant IgE ...
- Clostridium difficile toxin peptide acts as mucosal adjuvant.
- Newspaper article from: Drug Week July 9, 2004 700+ words
...ribosyltransferase activity acts as a mucosal adjuvant. "The receptor binding domains of...toxin A prompted us to investigate the mucosal adjuvant properties of a nontoxigenic peptide...antigens and represents a promising mucosal adjuvant, especially because its ability to...
- Antex Biologics And U.S. Navy Initiate Trial Of Campylobacter Vaccine; Vaccine...
- Press release article from: PR Newswire September 20, 1996 700+ words
...Campylobacter vaccine in combination with a mucosal adjuvant for the prevention of gastroenteritis...and immunogenic. The addition of a mucosal adjuvant should substantially improve the immune...longer duration of protection. The mucosal adjuvant being evaluated in this study is a...
- Osaka University Extends Service Using Terabeam's Gigabit Ethernet System.
- Press release article from: Business Wire November 13, 2003 700+ words
...wireless systems, today announced that Osaka University has purchased Terabeam's high frequency...building on its campus in Osaka, Japan. Osaka University will be the first to deploy Terabeam...The Gigalink system will connect Osaka University's School of Telecommunications to...
- Osaka University Selects CoSy compiler development system from ACE Associated...
- Press release article from: Business Wire July 21, 2000 700+ words
...PEAS-III development project from Osaka University will utilize advanced compiler generation...needs of the application domain. Osaka University expects that CoSy will be able to...these dedicated processor cores. Osaka University believes the design methodologies...
- Investigators at Osaka University release new data on bioengineering.(Report)
- Newspaper article from: Biotech Week March 11, 2009 700+ words
...wrote N.N. Sang and colleagues, Osaka University (see also Bioengineering). The...additional information, contact S. Soda, Osaka University, Graduate School Engineering, Division...Bioscience Bioengineering Japan, Osaka University, Faculty Engineering, 2-1 Yamadaoka...
- Research from Osaka University in the area of science published.(Report)
- Newspaper article from: Journal of Mathematics November 3, 2009 700+ words
...wrote H. Nishiyama and colleagues, Osaka University. The researchers concluded: "Moreover...information, contact H. Nishiyama, Osaka University, Graduate School Science, Dept...is: Osaka Journal of Mathematics, Osaka University Dept. Mathematics, Toyonaka, Osaka...
- Scientists at Osaka University release new data on life sciences.
- Newspaper article from: Biotech Week September 3, 2008 700+ words
...wrote S.Y. Lee and colleagues, Osaka University. The researchers concluded: "Discovery...information, contact T. Nihira, Osaka University, International Center Biotechnology...Bioscience Bioengineering Japan, Osaka University, Faculty Engineering, 2-1 Yamadaoka...
- Research from Osaka University in bioengineering provides new insights.
- Newspaper article from: Biotech Week March 11, 2009 700+ words
...wrote K. Sakai and colleagues, Osaka University (see also Bioengineering). The...information, contact T. Nihira, Osaka University, International Center Biotechnology...Bioscience Bioengineering Japan, Osaka University, Faculty Engineering, 2-1 Yamadaoka...
Source: HighBeam Research, Novel mucosal adjuvant safe, effective.