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Novel noncytotoxic vaginal microbicide may help prevent HIV and other infections.(SAMMA)
2002 NOV 14 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have identified a promising microbicidal agent that may help prevent HIV and other sexually transmitted infections.
"Presently marketed vaginal barrier methods are cytotoxic and damaging to the vaginal epithelium and natural vaginal flora when used frequently," according to Betsy C. Herold and colleagues at Mount Sinai School of Medicine in New York City, Rush University in Chicago, and the University of Illinois at Chicago.
A mandelic acid condensation polymer - dubbed SAMMA - appears to protect against sexually transmitted viruses without damaging healthy cells or beneficial organisms, Herold and coauthors found.
The researchers assessed SAMMA's efficacy against clinical and laboratory strains of HIV and herpes simplex virus (HSV). The microbicide potently suppressed HIV infection of human macrophages and peripheral blood cells, with equally strong activity against macrophage- and T cell-tropic HIV strains, they reported.
SAMMA treatment also protected cervical epithelial cells from infection with HSV, study data showed. Importantly, this agent's antiviral activity was both powerful and highly selective, with almost no ...
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Source: HighBeam Research, Novel noncytotoxic vaginal microbicide may help prevent HIV and other...