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Glycoprotein associates with uterine growths, may impair fertility.(uterine fibroids)
2002 NOV 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - High levels of glycodelin may be associated with uterine fibroids, uterine polyps, and infertility.
Medical researchers at Emory University in Atlanta, Georgia, believe uterine tumors produce elevated levels of the protein, and it may be a cause of infertility when produced during certain phases of the menstrual cycle.
"Glycodelin, a glycoprotein, is present in both blood plasma and uterine flushings," said Spencer S. Richlin and Emory School of Medicine coauthors. "It has been implicated in the process of implantation and angiogenesis."
Researchers say that during the secretory phase of a woman's menstrual cycle glycodelin production accompanies progesterone expression.
For the Emory study, researchers collected uterine flushings from 47 women with infertility problems who were in the proliferative phase of their cycles.
With the aid of transvaginal ultrasounds, investigators were able to categorize the women by the presence of polyps or leiomyomas, also known as uterine fibroids. Women without either type of tumor served as study controls.
Glycodelin levels were significantly increased in the uterine flushings of women with polyps, and elevated, but not significantly so, in the uterine flushings of those with leiomyomas.
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Source: HighBeam Research, Glycoprotein associates with uterine growths, may impair...