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SOURCE: Science, January 11, 1991; 251(4990):195-198.
Some vaccines - particularly new types of peptide and recombinant virus vaccines that present only one or a few epitopes - may combine with other factors to cause and not prevent disease, a Swiss research team warns.
As these types of vaccine are currently being explored in the search for an HIV vaccine, the warning is especially relevant to AIDS research.
University of Zurich researchers Stephan Oehen, Hans Hengartner, and Rolf M. Zinkernagel conducted a series of experiments with recombinant vaccinia virus vaccines against lymphocytic choriomeningitis virus (LCMV) in mice.