AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Malaria-infected blood cells stimulate protective immune response.
2002 OCT 23 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Volunteers who received multiple vaccinations of a low dose of red blood cells infected with Plasmodium falciparum developed immunity against malaria, according to a report in the journal Lancet.
"The ability of T cells, acting independently of antibodies, to control malaria parasite growth in people has not been defined," said David J. Pombo at the Cooperative Research Centre for Vaccine Technology in Australia and colleagues in Australia, Thailand, and the U.S. "If such cell-mediated immunity was shown to be effective, an additional vaccine strategy could be pursued."
The investigators inoculated five volunteers with multiple low doses of malaria-infected (P. falciparum strain 3D7) red blood cells. The infections produced after each injection were cured with antimalarial drugs (Immunity to malaria after administration of ultra-low doses of red blood cells infected with Plasmodium falciparum. Lancet, 2002;360(9333):610-617).
The cellular and antibody responses to the injections were determined. Immunity was determined by the detection or absence of the STEVOR gene after polymerase chain reaction (PCR) testing and clinical signs and symptoms of malaria.
All of the volunteers eventually exhibited immunity against malaria by remaining free of P. falciparum DNA and failing to develop clinical signs and symptoms of the disease. Interestingly, an antibody response was not associated with the development of immunity. Instead, the proliferation of ...
- Researchers identify new way the malaria parasite and red blood cells interact.
- Newspaper article from: NewsRx Health & Science March 29, 2009 700+ words
...mechanism the malaria parasite uses...enter human red blood cells, which could...of human red blood cells, is important...invasion of the malaria parasite...examined how the malaria parasite...interacts with red blood cells using a biochemical...
- Protein Potential LLC Announces that a Structural Basis for Malaria Parasite...
- Press release article from: PR Newswire September 8, 2005 700+ words
...PRNewswire/ -- For malaria parasites to...invade the red blood cells of humans...invasion of red blood cells, and vaccines...monkeys against malaria. Recently Dr...critical to malaria parasite invasion of red blood cells to be able to...
- Red Blood Cells & CFIDS.(chronic fatigue immune deficiency syndrome)
- Magazine article from: Townsend Letter for Doctors and Patients Klotter, Jule November 1, 2001 700+ words
...Abnormal red blood cells lack flexibility...Huntington's disease, malaria, and diabetes...mechanism whereby red blood cells revert to the discocyte...Huntington's disease, malaria, and diabetes...mechanism whereby red blood cells revert to the discocyte...
- Fewer red blood cells; Anemia can impair one's ability to do simple tasks.(LIFE...
- Newspaper article from: The Washington Times August 16, 2005 700+ words
...destruction of red blood cells, says Dr. Lawrence...produce all types of blood cells. Many children...parasites, such as malaria. "It's an extremely...order to survive malaria, he says. A person...tissues, the red blood cells change shape...
- Conversion of stem cells to blood cells may replenish supplies.(Stem...
- Magazine article from: Chemistry and Industry Winder, Robert July 4, 2005 700+ words
...large quantities of blood cells. Blood for transfusion...and diseases such as malaria and West Nile. Stem...previously to produce blood cells, but researchers Andrew...grow larger numbers of blood cells from human embryonic...
- Plasmodial EBA-140 protein peptides protect blood cells from infection.
- Newspaper article from: Malaria Weekly (Atlanta, GA) January 12, 2004 700+ words
...protein peptides can help protect blood cells from malaria infection. In a recent study...peptides that bind to human red blood cells. J Pept Res, 2003;62(4...This article was prepared by Malaria Weekly editors from staff and...
- Researchers Uncover New Clinical Syndrome: Destruction of Red Blood Cells Tied...
- Press release article from: PR Newswire April 5, 2005 700+ words
...hemolysis, the destruction of red blood cells. The syndrome includes symptoms...nocturnal hemoglobinuria (PNH), malaria, and certain anemias, including...begins with the destruction of red blood cells and leads to elevated levels of...
- Sickle Cell Anemia.(Disorders of the Red Blood Cells)
- The Columbia Univ. Coll. of Physicians & Surgeons Complete Home Medical Guide Bank, Arthur January 1, 1995 700+ words
...sickle hemoglobin to be carried by the red blood cells. Cause Sickle cell anemia is inherited...recessive gene. In areas of the world where malaria is common, individuals with sickle cell...a favorable adaptational response to malaria. But children who inherit the sickle...
Source: HighBeam Research, Malaria-infected blood cells stimulate protective immune response.