AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Cloned T9 cells protect against intracranial glioma tumors.
2002 OCT 23 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Immunity against intracranial T9 gliomas was conferred by treatment of rats with live cloned T9-C2 glioma cells that expressed macrophage colony-stimulating factor (mM-CSF), according to a report by researchers from the U.S.
Yijun Chen and colleagues at the University of California-Irvine, and California State University and the Veterans Affairs Medical Center in Long Beach, found that control T9 glioma cells formed subcutaneous tumors in rats but cloned T9-C2 cells expressing mM-CSF or Bcl2 did not.
The mechanism of protection conferred by immunization using T9-C2 cells involved vacuolization of tumor cells mitochondria and endoplasmic reticula, which caused cell swelling and death within 24 hours. Cytokines produced by T9 and T9-C2 cells caused granulocyte accumulation at the tumor injection site. Macrophages also interacted with the tumor cells, causing death by methods other than phagocytosis (Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9 gliomas. Blood, 2002;100(4):1373-1380).
The involvement of both macrophages and polymorphonuclear (PMN) leukocytes was demonstrated by treating athymic rats with antibodies against PMN leukocytes and/or macrophages. Only 40% of the rats given one of the antibodies developed T9-C2 tumors while 80% of the rats given both antibodies developed tumors. Rats able to ...
- Researchers draw anti-tumor cells to brain.
- News wire article from: UPI NewsTrack January 12, 2009 700+ words
...recognized and attacked tumor cells. The Cedars-Sinai Medical Center researchers in Los Angeles...HMGB1, released from dying tumor cells activates key immune cells...against the tumors, killing tumor cells and eliciting long-term...
- Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor...
- Newspaper article from: Biotech Week May 6, 2009 700+ words
...Georgetown University Medical Center have demonstrated...a variety of tumor cells (see also Georgetown University Medical Center). Mutations...expressing tumor cells. This novel...Georgetown University Medical Center. This article...
- Pituitary tumor cells found to express large amounts of protein receptor.
- Newspaper article from: Proteomics Weekly November 25, 2002 700+ words
...Center at Cedars-Sinai Medical Center. "We will soon begin...receptor on pituitary tumor cells indicates that PPAR...Institute at Cedars-Sinai Medical Center. Based on these findings...tested whether pituitary tumor cells would respond to drugs...
- Level of Circulating Tumor Cells in Bloodstream Predicts Breast Cancer...
- Press release article from: PR Newswire August 18, 2004 700+ words
...level of circulating tumor cells in the bloodstream before...enabled the detection of tumor cells. For this study, the evaluation of circulating tumor cells was conducted in one...multispecialty academic medical center that integrates clinical...
- Researchers explore turning on immune system to attack tumor cells.
- Newspaper article from: Cancer Vaccine Week March 24, 2003 700+ words
...cells can identify dying tumor cells in the body, not just tumor cells they are exposed to in the...tumors, Black directs the medical center's division of neurosurgery...gliomas that contained some tumor cells that had been exposed to...
- Researchers explore turning on immune system to attack tumor cells.(brain...
- Newspaper article from: Cancer Weekly March 25, 2003 700+ words
...cells can identify dying tumor cells in the body, not just tumor cells they are exposed to in the...tumors, Black directs the medical center's division of neurosurgery...gliomas that contained some tumor cells that had been exposed to...
- Researchers explore turning on immune system to attack tumor cells.(brain...
- Newspaper article from: Vaccine Weekly March 26, 2003 700+ words
...cells can identify dying tumor cells in the body, not just tumor cells they are exposed to in the...tumors, Black directs the medical center's division of neurosurgery...gliomas that contained some tumor cells that had been exposed to...
- Gene courier targets skin-tumor cells. (liposomes used to carry therapeutic...
- Magazine article from: Science News Fackelmann, Kathy A. December 4, 1993 700+ words
...University of Michigan Medical Center in Ann Arbor, and...also usher DNA into tumor cells in the human body...then recognize those tumor cells as foreign and mount...Only a fraction of tumor cells take up the gene...
- Circulating tumor cells may be better marker than...
- Magazine article from: Internal Medicine News Dixon, Bruce K. September 1, 2007 700+ words
CHICAGO -- An assay to calculate circulating tumor cells may be superior to PSA as a surrogate marker for survival...discussant Dr. Daniel P. Petrylak of Columbia-Presbyterian Medical Center in New York. "We do need to correlate pretreatment...
- Scientists nip would-be tumor cells before they can bud.(The Dallas Morning...
- Newspaper article from: Knight Ridder/Tribune News Service Ambrose, Sue Goetinck January 8, 2001 700+ words
DALLAS _ Dallas scientists have nipped would-be tumor cells before they could bud, potentially boosting the arsenal...researchers, from the University of Texas Southwestern Medical Center at Dallas, discovered a treatment that, in laboratory...
Source: HighBeam Research, Cloned T9 cells protect against intracranial glioma tumors.