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2002 OCT 23 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Just two doses of hepatitis B virus vaccine administered 12 months apart can protect adolescents from viral infection, according to a published report.
Typically, hepatitis B virus (HBV) vaccine regimens are completed with one or two additional doses of vaccine being given within 6 months of the first dose. Now though, investigators at Liverpool Hospital in Sydney, Australia have established that better vaccine coverage might be obtained by vaccinating adolescents every 12 months, when it may be more practical to offer successive doses in environments such as schools.
The Australian HBV vaccine study initially included 484 youth in their first year of high school, according to Leon G. Heron of the South Western Sydney Public Health Unit of Liverpool Hospital. Heron and colleagues in the Epidemiology Unit collected baseline serum samples on the day of the first vaccination, and approximately a month after the second dose was administered a year later.
For a variety of reasons, 387 students with data for both serum samples were ultimately included in the data set. Some of the other students had already been vaccinated, withdrew from the study or were omitted for other reasons.
Over 97% of the 387 youth developed antibody levels high enough ...
Source: HighBeam Research, Novel 12-month regimen protects youth after hepatitis B vaccination.