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British study results support fetal insulin hypothesis.
2002 OCT 24 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Data from the British Women's Heart and Health Study demonstrated that a women's risk of developing insulin resistance was inversely related to the birth weight of her offspring, a result that surprised investigators.
"We expected birth weight of offspring to be positively associated with maternal insulin resistance in later life, since maternal gestational diabetes is associated with increased birth weight of offspring and also with maternal diabetes in later life," said Debbie A. Lawlor and colleagues at the University of Bristol in Great Britain.
Lawlor and her collaborators used questionnaires, interviews, and examinations to collect data on 4286 women, 60-79 years old, from 23 towns throughout Great Britain. The data were analyzed to determine if an association existed between insulin resistance and offspring birth weight.
Women were 15% less likely to be in the highest quartile of insulin resistance risk for each 1 kg higher offspring birth weight. After controlling for possible confounding factors, this value increased to 27%. The association between maternal insulin resistance and offspring birth weight was not linear. Instead, it was U-shaped, with the women having the lightest and heaviest offspring being most likely to have diabetes later in life.
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