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Gene mutations reviewed.
2002 OCT 24 - (NewsRx.com & NewsRx.net) -- A review article in the Lancet assesses the impact of BRCA1 gene mutations - known to be strongly associated with an increased risk of breast and ovarian cancer - on the management of patients.
The BRCA1 gene was identified in 1990 and cloned in 1994. Around 1 in 500 to 1 in 800 women have a BRCA1 gene mutation; women with familial breast or ovarian cancer have a germline mutation of the gene, which gives them a lifetime risk of breast cancer of around 50-85%, and ovarian cancer of 15-60%. Although a genetic test for identification of high-risk individuals has been developed, the underlying mechanisms of how inactivation of the BRCA1 gene leads to malignant cell growth is not fully understood. .
Paul Harkin and Richard Kennedy from Queens University, Belfast, and colleagues examined the mechanisms that underlie inactivation of BRCA1 and assessed how they affected the management of patients, in terms of both primary (e.g., prophylactic surgery such as mastectomy or oopherectomy and preventative use ...
- Many Opt for Surgery to Lower Breast, Ovarian Cancer Risk; Women with BRCA gene...
- News wire article from: Consumer Health News (English) August 7, 2009 700+ words
...risk of breast or ovarian cancer have surgery to remove...with BRCA1 or BRCA2 gene mutations, which are known...risk of breast and ovarian cancer. The women found...with BRCA1 and BRCA2 gene mutations had both breasts removed...
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- Newspaper article from: Obesity, Fitness & Wellness Week June 26, 2004 700+ words
...prevention in Belgian breast/ovarian cancer families." Claes and colleagues...frequencies in Belgian breast/ovarian cancer families. Br J Cancer...major subject areas of BRCA Gene Mutations, Breast Cancer, Ovarian Cancer, Oncology, Epidemiology...
- USPSTF advises against routine BRCA screening: women with a family history of...
- Magazine article from: Internal Medicine News Pfeiffer, Amy November 15, 2005 700+ words
...breast and ovarian cancer risk based on gene mutations unless they...breast and ovarian cancer undergo genetic...screening for gene mutations if they are...have BRCA gene mutations to reduce breast and ovarian cancer risk include...
- ESTIMATING ADVERSE SELECTION COSTS FROM GENETIC TESTING FOR BREAST AND OVARIAN...
- Magazine article from: Journal of Risk and Insurance Subramanian, Krupa Lemaire, Jean Hershey, John C. Pauly, Mark V. Armstrong, Katrina Asch, David A. December 1, 1999 700+ words
...testing for breast and ovarian cancer. Increased forces...Several years ago, two gene mutations that affect the likelihood...developing breast and ovarian cancer were discovered...death for breast or ovarian cancer may purchase more...
- ESTIMATING ADVERSE SELECTION COSTS FROM GENETIC TESTING FOR BREAST AND OVARIAN...
- Magazine article from: Journal of Risk and Insurance Subramanian, Krupa Lemaire, Jean Hershey, John C. Pauly, Mark V. Armstrong, Katrina Asch, David A. December 1, 1999 700+ words
...testing for breast and ovarian cancer. Increased forces...Several years ago, two gene mutations that affect the likelihood...developing breast and ovarian cancer were discovered...death for breast or ovarian cancer may purchase more...
- NorthShore University HealthSystem Researcher Calls for Open Dialogue on Need...
- News wire article from: PRWeb July 16, 2009 700+ words
...developing breast or ovarian cancer. Previous...they have BRCA gene mutations because there...of breast or ovarian cancer. "If a woman...Rubinstein. "BRCA gene mutations may be masked...focused on ovarian cancer. Unlike breast...
- Genetic testing for breast or ovarian cancer risk may be greatly underutilized.
- Magazine article from: Women's Health Weekly June 11, 2009 700+ words
Although a test for gene mutations known to significantly increase...of hereditary breast or ovarian cancer has been available for more...percent, and the risk for ovarian cancer is less than 2 percent...times more likely to develop ovarian cancer than women with ...
- ACS, Myriad Genetic Labs begin long-term study of breast and ovarian cancer...
- Newspaper article from: Transplant News August 28, 1996 700+ words
...analysis for breast and ovarian cancer susceptibility in...hereditary breast and ovarian cancer. It will address...risk of breast and ovarian cancer? In women who have cancer-predisposing gene mutations, how effective are...
