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Enterovirus infection during pregnancy does not increase diabetes risk of the exposed fetus.
2002 OCT 17 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Children born to women who contracted an enterovirus infection in the first trimester of pregnancy are not at any increased risk of developing type 1 diabetes, according to a report in the journal Diabetes.
"Previous studies have suggested that enterovirus infections during pregnancy may increase the risk of type 1 diabetes in the offspring," explained Hanna R. Viskari and colleagues at the University of Tampere and the Juvenile Diabetes Foundation International Center for the Prevention of type 1 diabetes in Finland. "Our aim was to evaluate the role of first trimester enterovirus infections in a larger cohort of pregnant women."
The investigators examined data on 1628 women, 948 (series 1) who had a child who developed diabetes before the age of 15 years and 680 (series 2) who had a child who developed diabetes before the age of 7 years. Control groups containing equal numbers of women with nondiabetic children were also established.
For women in series 1, an acute enterovirus infection was diagnosed based on the level of anti-coxsackievirus-B5 IgM antibodies. For women in series 2, infection diagnosis was based on the detection of specific anti-enterovirus-peptide IgG antibodies, and IgM antibodies against coxsackievirus B3, coxsackievirus A16, and echovirus 11 antigens. A test for enterovirus RNA was done for women with IgM-positive sera and 152 additional case-control pairs.
Fewer women in series 1 had anti-coxsackievirus-B5 IgM antibodies compared with the control women (3.1% vs. 4.1%, respectively), but the difference was not statistically significant. More women in series 2 had enterovirus-related IgM antibodies compared with the controls (7.1% vs. 5.3%, ...
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Source: HighBeam Research, Enterovirus infection during pregnancy does not increase diabetes...