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Human papillomavirus may evade immune system by suppressing NF-kappaB activity.(Brief Article)
2002 OCT 17 - (NewsRx.com & NewsRx.net) -- Human papillomavirus infection, which can lead to cervical cancer, may be able to elude immune system activity by suppressing NF-kappa B, according to recent study findings.
"Infection with high-risk human papillomaviruses (HPV) can lead to the development of cervical carcinomas. This process critically depends on the virus-encoded E6 and E7 oncoproteins, which stimulate proliferation by manipulating the function of a variety of host key regulatory proteins," stated D. Spitkovsky and colleagues, University of Bern, Switzerland.
The researchers found "that both viral proteins dose-dependently interfere with the transcriptional activity of NF-kappaB."
"A variety of experimental approaches revealed that a fraction of the E7 proteins is found in association with the IkappaB kinase complex and attenuates induced kinase activity of IkappaB kinase alpha (IKKalpha) and IKKbeta, thus resulting in impaired IkappaBalpha phosphorylation and degradation," wrote Spitkovsky and coauthors.
"Indirect immunofluorescence shows that E7 impairs TNF-alpha-induced nuclear translocation of NF-kappaB, thus preventing NF-kappaB from binding to its cognate DNA. ...
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Source: HighBeam Research, Human papillomavirus may evade immune system by suppressing NF-kappaB...