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Study finds morphine promotes breast tumor growth.(Brief Article)
2002 OCT 17 - (NewsRx.com & NewsRx.net) -- Findings from a recent study indicate that morphine, commonly used to treat cancer-caused pain, promotes tumor neovascularization and so could be harmful in breast cancer patients.
In a paper in the journal Cancer Research, K. Gupta and colleagues presented data demonstrating "that morphine, in a concentration typical of that observed in patients' blood, stimulates human microvascular endothelial cell proliferation and angiogenesis in vitro and in vivo. It does so by activating mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation via Gi/Go-coupled G protein receptors and nitric oxide in these microvascular endothelial cells."
They continued: "Other contributing effects of morphine include activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1."
Thus, Gupta and colleagues concluded that "[c]onsistent with these effects, morphine ...
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Source: HighBeam Research, Study finds morphine promotes breast tumor growth.(Brief Article)