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New data published on novel mode of action of Modrenal.
2002 OCT 17 - (NewsRx.com & NewsRx.net) -- Bioenvision, Inc., (BIOV) announced that new data on the novel mode of action of Modrenal has been published in Cancer Cell Biology.
Modrenal is approved for marketing in the U.K. for the treatment of advanced breast cancer in postmenopausal women.
The published results are the culmination of extensive work by a team from the Division of Biomedical Sciences at Queen Mary and Westfield College, London. They show that Modrenal works on cancer cells in a previously unrecognized way that clearly distinguishes it from other breast cancer treatments. Until the publication of these data it was thought that Modrenal acted solely by inhibiting the synthesis of oestrogen.
However, it has long been recognized that this action alone was insufficient to fully explain the beneficial clinical results of Modrenal. The new results show that Modrenal, in addition to inhibiting production of oestrogen, also has a novel action on the oestrogen receptors.
Christopher B. Wood, MD, president and CEO of Bioenvision, commented, "This new data further support previous results which have been published showing the benefits of Modrenal to patients that have relapsed following other hormonal treatments, such as tamoxifen. We are honored and pleased that Cancer Cell Biology, one of the world's premier cancer journal, accepted the data for ...
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...In extensive clinical trials Modrenal(TM) has been shown to have...receptor, ER-beta. Thus, Modrenal(TM) has become the first...steroid binding to ER-beta. New data has shown that this particular mode of action could give Modrenal(TM) a role in prostate...
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...Bioenvision Inc announced that new data on the novel mode of action of Modrenal has been published in Cancer Cell Biology. Modrenal is approved for marketing in the...College, London. They show that Modrenal works on cancer cells in a previously...
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...importance of Bioenvision's Modrenal(R) (trilostane) as a valuable...sensitive breast cancers. These new data were presented at the 8th Nottingham...NIBC) earlier this month. Modrenal has obtained regulatory approval...were subsequently treated with Modrenal, clinicians observed clinical...
- Bioenvision Obtains U.K. Marketing Rights to Modrenal.
- Press release article from: Business Wire August 20, 2003 700+ words
...it has obtained the rights to market Modrenal(TM) (trilostane), its approved...receive all revenue streams for sales of Modrenal as of January 1, 2003. "We received...releasing our positive data in May regarding Modrenal's unique dual mode of action," said...
- Bioenvision Announces New Breast Cancer Studies with Modrenal.
- Press release article from: Business Wire December 5, 2003 700+ words
...for its lead breast cancer treatment Modrenal(R) (trilostane). The announcement...menopausal Phase IV study is to confirm Modrenal's proven clinical benefit in patients...breast cancer patients will evaluate Modrenal's efficacy following relapse to first...
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- Press release article from: Business Wire June 4, 2003 700+ words
...it has launched its approved therapy, Modrenal (trilostane), in the United Kingdom...had received other therapies prior to Modrenal, and many had failed tamoxifen and...inhibitors. Bioenvision believes that Modrenal has two unique mechanisms of action...
- First Patients Enrolled in Three Breast Cancer Studies for Bioenvision's...
- Press release article from: Business Wire November 17, 2005 700+ words
...three separate, clinical studies of Modrenal(R) (trilostane). These studies are investigating the efficacy of Modrenal in three distinct settings: (1...3) a Phase II trial utilizing Modrenal(R) as a neo-adjuvant (pre...
- First Patients Enrolled in Phase II and Phase IV Breast Cancer Studies for...
- Press release article from: Business Wire September 21, 2005 700+ words
...enrolled in a Phase IV clinical study of Modrenal(R) (trilostane) in post-menopausal...designed to evaluate the efficacy of Modrenal(R) in patients who have failed prior...Bioenvision's Chief Operating Officer. Modrenal is licensed in the UK to treat post...
Source: HighBeam Research, New data published on novel mode of action of Modrenal.