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Neuropilin-1 a multifunctional protein for progression in breast cancer.(Brief Article)
2002 OCT 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Both conventional and novel genetic fingerprinting techniques have confirmed neuropilin-1 protein stimulates mechanisms associated with breast cancer progression.
According to medical investigators in Kansas City, Missouri, at the University of Kansas Medical Center, neuropilin-1 (NRP-1) reactivity is detected primarily in myoepithelial cells of the mammary duct and lobules, but not in the innermost epithelial cell layers of those breast tissues. NRP-1 may be a useful predictor for breast cancer progression, the researchers say.
"The myoepithelial cells of ducts and lobules in both neoplastic and nonneoplastic tissue specimens displayed a stronger positive reaction for NRP-1 than those in the normal breast," described John M. Stephenson and colleagues.
Tissues with atypical epithelial hyperplasia as well those of ductal carcinoma in situ were reactive for NRP-1, although at varying levels (Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: A possible marker for the progression of breast cancer. International Journal of Cancer, October 2002;101(5):409-414).
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