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Dead tumor cells contribute to immunogenicity of vaccine.
2002 OCT 16 - (NewsRx.com & NewsRx.net) -- Avax Technologies, Inc., (AVXT) announced the publication of a scientific paper on studies of its AC Vaccine technology for the treatment of cancer.
The paper, by David Berd, Department of Medicine, Kimmel Cancer Center, Thomas Jefferson University, and a consultant to the company, was published in the journal Cancer Immunology, Immunotherapy.
The paper was a retrospective analysis of dosing regimens given to 284 melanoma patients to determine the impact of live and dead cells in eliciting an immune response, as measured by delayed type hypersensitivity testing (DTH), to their own tumor cells. The paper concludes that dead tumor cells (tumor cells that are intact, but do not exclude the dye trypan blue) appear to contribute to the immunogenicity of the vaccine.
As previously published by Berd and as reported by the company, the DTH response to unmodified tumor cells was a significant and independent predictor of 5-year survival in studies involving 214 melanoma patients. Additionally, Avax, through its product development initiatives, has recently completed mouse studies comparing the original "fresh" vaccine technology, which was the form of vaccine used for treatment of patients in these prior clinical studies, to a newly developed "frozen" vaccine technology.
Although the proportion of dead cells was higher in the frozen vaccine, the frozen vaccine produced relapse-free survival similar to that produced by the fresh vaccine, which was significantly better than that seen in control groups.
David Tousley, president and chief operating officer of Avax, stated, "We are happy to see the results of this important paper published. The data that was the basis for this paper has been valuable to Avax in making the decision to undergo ...
- Dead tumor cells contribute to immunogenicity of vaccine.(AC Vaccine technology...
- Newspaper article from: Cancer Weekly October 15, 2002 700+ words
...The paper concludes that dead tumor cells (tumor cells that are intact, but do not...DTH response to unmodified tumor cells was a significant and independent...studies, to a newly developed "frozen" vaccine technology. Although the proportion...
- Dead tumor cells contribute to immunogenicity of vaccine.
- Newspaper article from: Biotech Week October 16, 2002 700+ words
...The paper concludes that dead tumor cells (tumor cells that are intact, but do not...DTH response to unmodified tumor cells was a significant and independent...studies, to a newly developed "frozen" vaccine technology. Although the proportion...
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- Newspaper article from: Biotech Week May 7, 2003 700+ words
...If patients with breast cancer have tumor cells circulating in the blood, they may...Research, found that women who have tumor cells circulating in the blood have reduced...compared to those without circulating tumor cells. Until recently, doctors have not...
- Dead tumor cells improve melanoma vaccine immunogenicity.
- Newspaper article from: Cancer Weekly October 15, 2002 700+ words
...medical writer - A higher number of dead tumor cells in a vaccine containing autologous melanoma tumor cells increased the delayed-type hypersensitivity...with a vaccine consisting of autologous tumor cells modified with the hapten, dinitrophenyl...
- Cancer Immunotherapy IL-2 Interaction is More Effective in Fas(+) Tumor Cells.
- Newspaper article from: Immunotherapy Weekly January 11, 1999 700+ words
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