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Tumor cells overexpressing heat shock protein effectively inhibit murine colon cancer growth.
2002 OCT 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Growth of a murine CT26 colon carcinoma was completely inhibited by immunization of the mice with a vaccine containing a heat shock protein and cells that produced granulocyte-macrophage colony stimulating factor (GM-CSF).
"Several studies have suggested a positive correlation between heat shock protein (hsp) expression and tumor immunogenicity," commented Xiang-Yang Wang and colleagues at the Roswell Park Cancer Institute in Buffalo, New York. "Independently, many studies have shown that hsp purified from tumors can be used as a tumor-specific vaccine."
The investigators incorporated the cDNA of heat shock protein 110 (hsp110) in murine CT26 colon carcinoma cells (CT26-hs110). In vitro, overexpression of the hsp did not affect tumor growth, but hsp-expressing tumors established in mice did grow significantly more slowly than wild-type CT26 tumors.
Vaccination of mice with inactivated CT26-hsp110 cells caused the proliferation of CD8+ (but not CD4+) tumor-specific T cells and natural killer (NK) cells and significantly inhibited the growth of wild-type CT26 tumors. Addition of GM-CSF-producing cells to the CT26-hsp110 cell vaccine completely prevented the growth of wild-type CT26 tumors.
"These observations demonstrate that ...
- New U.S. composition patent firmly solidifies Stressgen's position in heat...
- Press release article from: PR Newswire January 15, 2002 700+ words
...fusion proteins comprised of a heat shock protein fused to any antigen. Further...our position in the field of heat shock protein fusions. The pre-GATT 17...technology for developing multiple heat shock protein fusions will remain proprietary...
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- Press release article from: PR Newswire September 30, 2002 700+ words
...leader in the development of heat shock protein-based immunotherapies, announced...ways of utilizing existing heat shock protein-based vaccines as well as...increasing the effectiveness of heat shock protein vaccines and the development...
- High-throughput screening detects heat-shock protein 90 ATPase inhibitors.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...throughput screening detects heat-shock protein 90 ATPase inhibitors. "The molecular chaperone heat-shock protein 90 (HSP90) plays a key role...screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal...
- Stressgen obtains new European patent for heat shock protein fusions.(European...
- Newspaper article from: BIOTECH Patent News January 1, 2002 700+ words
...fusion proteins comprised of heat shock proteins fused to antigens...0900). Using this patented heat shock protein 'fusion' technology, Stressgen...patent received this month on our heat shock protein 'fusion' technology," said...
- Stressgen announces issuance of U.S. patent solidifying its heat shock...
- Press release article from: PR Newswire January 4, 2002 700+ words
...our technology for developing heat shock protein fusions to treat viral diseases...market a compound such as our heat shock protein fusion candidate, HspE7...research studies to evaluate its heat shock protein 'fusion' technology in the...
- Upregulated heat shock protein 70 protects against tumor growth in mice.
- Newspaper article from: Cancer Vaccine Week May 17, 2004 700+ words
...NewsRx.net) -- Upregulated heat shock protein 70 protects against tumor growth in mice. "Although heat-shock protein 70 (Hsp70) has been considered...Cancer (Forced expression of heat-shock protein 70 increases the secretion...
- Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity.
- Newspaper article from: Cancer Gene Therapy Week January 19, 2004 700+ words
...com & NewsRx.net) -- Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity. "Heat shock proteins (HSPs) are recognized...study in Cancer Gene Therapy (Heat shock protein 70 gene therapy combined with...
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- Magazine article from: Environmental Health Perspectives Mukhopadhyay, Indranil Saxena, Daya Krishna Chowdhuri, Debapratim Kar December 1, 2003 700+ words
...concurrent with the expression pattern of the heat shock protein 70 gene (hsp70), both in larval tissues...structure and function. Among the different heat shock proteins, the stress-inducible heat shock protein 70 (Hsp70) family is the most conserved...
- Studies Indicate That Schisandrin B Can Induce Heat Shock Protein Production in...
- Press release article from: Business Wire June 15, 2007 700+ words
...whether Schisandrin B can induce heat shock protein production in heart tissues...protection against I-R injury. Heat shock protein is a universal cell protectant...that Schisandrin B can induce heat shock protein production in the heart, which...
- Therapies that exploit heat shock protein 90 target cancer growth.
- Newspaper article from: Health & Medicine Week May 24, 2004 700+ words
...amp; NewsRx.net) -- Therapies that exploit heat shock protein 90 target cancer growth. According to a study from England, "the molecular chaperone heat shock protein (Hsp)90 is not only of major current interest...
Source: HighBeam Research, Tumor cells overexpressing heat shock protein effectively inhibit...