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Dead tumor cells improve melanoma vaccine immunogenicity.
2002 OCT 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A higher number of dead tumor cells in a vaccine containing autologous melanoma tumor cells increased the delayed-type hypersensitivity response in melanoma patients, according to investigators in the U.S.
"We have reported that treatment of melanoma patients with a vaccine consisting of autologous tumor cells modified with the hapten, dinitrophenyl (DNP) and preceded by low-dose cyclophosphamide induces delayed-type hypersensitivity (DTH) to autologous, unmodified tumor cells and that this response is a significant predictor of survival," said David Berd and colleagues at Thomas Jefferson University in Philadelphia.
The investigators examined the characteristics of melanoma vaccines administered to 284 patients who had undergone surgery for malignant melanoma. After vaccination, 161 (57%) of the patients exhibited a DTH reaction of at least 5 mm induration to unmodified autologous tumor cells. No association was found between the number of live melanoma cells in a vaccine dose and the extent of the DTH response (Effect of the dose and composition of an analogous hapten-modified melanoma vaccine on the development of delayed-type hypersensitivity responses. Cancer Immunology Immunotherapy, 2002;51(6):320-326).
However, a significant association was found between the average percentage of dead melanoma cells in the vaccines given to a patient and that patient's maximum DTH response. Sixty-five percent of patients who received vaccines averaging greater than 75% dead cells had ...
- Dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha.
- Newspaper article from: Biotech Week December 29, 2004 700+ words
...dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha...cells (Mo-DCs) that capture dead tumor cells (Mo-DCs-Tum) secrete interleukin...dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha...
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- Newspaper article from: Clinical Oncology Alert November 1, 2004 700+ words
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- Press release article from: PR Newswire August 18, 2004 700+ words
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- Newspaper article from: Biotech Week July 7, 2004 700+ words
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- Press release article from: PR Newswire July 20, 2004 700+ words
...the isolation of circulating tumor cells in the blood of cancer patients...isolation and analysis of circulating tumor cells, frequently associated with...technology, enriches circulating tumor cells directly from samples of cancer...
Source: HighBeam Research, Dead tumor cells improve melanoma vaccine immunogenicity.