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Vaccine reduces metastases after laparotomy.(pulmonary metastases)
2002 OCT 16 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Perioperative stimulation of the immune system with a vaccine consisting of lysed adenocarcinoma cells and an adjuvant reduced the number of pulmonary metastases after laparotomy in a murine model.
"Subcutaneous tumor growth and establishment is increased after laparotomy; significantly smaller increases have been noted after CO[subscript]2 pneumoperitoneum (CO[subscript]2 pneumo)," explained P. Wildbrett and colleagues at Columbia University in New York City. "The extent of surgical abdominal wall trauma also correlates with the extent of early postoperative immunosuppression and the inflammatory response. These changes may favor lung metastases (mets) formation."
The investigators assigned groups of 20 mice to receive either anesthesia control (AC), sham laparotomy (OP), OP plus treatment with monophosphoryl lipid A (MLPA), OP plus lysed adenocarcinoma tumor cells (LTC, 5 x 10[superscript]5 lysed TA3Ha tumor cells), or OP plus a vaccine containing MPLA and LTC.
MPLA was administered in five perioperative injections. The vaccine was administered in five preoperative and one postoperative injection. All mice received a tumor cell challenge after the sham surgery (Increased rates of pulmonary metastases following sham laparotomy compared to CO[subscript]2 pneumoperitoneum and the inhibition of metastases utilizing perioperative immunomodulation and a tumor vaccine. Surgical Endoscopy, 2002;16(8):1162-1169).
The median number of lung metastases was significantly lower in mice that received perioperative LTC (3 metastases, p
Mice that underwent OP plus MPLA developed fewer pulmonary metastases (4 metastases) than did the OP group (20 metastases), but this difference did not achieve ...
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