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Two new HRT reviews support findings of recently halted clinical trial.(Abstract)
2002 OCT 10 - (NewsRx.com & NewsRx.net) -- Two new systematic reviews of a broad spectrum of research on hormone replacement therapy (HRT) to prevent cardiovascular disease and other long-term health problems support the findings of a recently halted clinical trial in the Women's Health Initiative (WHI).
These reviews were developed for the U.S. Preventive Services Task Force as background for new recommendations on HRT use that will be published in the fall for clinicians and patients.
The two reviews, one in the Annals of Internal Medicine and the other in the Journal of the American Medical Association (JAMA), found that for women taking HRT for 5 years or longer to prevent chronic conditions, harms could exceed benefits.
The reviews were not able to determine whether the harms or benefits depended on type of hormones used. Although 1 study of estrogen and progestin in the WHI was stopped after 5 years because harms exceeded benefits, a second study of estrogen alone for women who have had a hysterectomy is continuing because the balance of benefits and harms is not yet clear.
The Annals article primarily addresses cardiovascular disease, and the JAMA article is an ...
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- Magazine article from: U.S. News & World Report November 18, 2002 700+ words
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- Newspaper article from: Knight Ridder/Tribune Business News October 16, 2002 700+ words
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- Press release article from: PR Newswire July 26, 2005 700+ words
...drug Prempro -- a low dose HRT drug -- for up to about eight...impairment," according to a task force supported by the HHS Agency...Women age 45 and older on HRT reported that prior to the therapy...vaginal dryness. But after HRT this number dropped only to...
Source: HighBeam Research, Two new HRT reviews support findings of recently halted clinical...