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Weight loss lowers leptin but raises soluble leptin receptor.(Abstract)
2002 OCT 10 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Profound weight loss resulted in a significant decrease in circulating leptin and increase in soluble leptin receptor levels, indicating an inverse regulatory relation between the two.
"Soluble leptin receptor (sOB-R) represents the main binding site for leptin in human blood," explained Markus Laimer and colleagues at the University of Innsbruck in Austria. "The aim of this study was to investigate the relationship between leptin and soluble leptin receptor and the bound/free ratio after pronounced weight reduction."
The investigators measured fat mass, leptin concentration, and sOB-R levels in 18 morbidly obese women before and 1 year following Swedish adjustable gastric banding surgery (Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. Obesity Research, 2002;10(7):597-601).
The women experienced significant reductions in body mass index (42.9 to 32.9 kg/m[superscript]2) and fat mass (56.3 to 33.9 kg) after surgery. A significant decrease in plasma leptin concentration (44.6 to 20.0 ng/mL, p
"This work demonstrates a relationship between weight loss, leptin, and sOB-R ...
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