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Tamoxifen shows encouraging results for prevention, but risks still unclear.(Abstract)
2002 OCT 10 - (NewsRx.com & NewsRx.net) -- Early findings from a randomized trial investigating the effectiveness of tamoxifen to prevent breast cancer are reported in the Lancet.
Although tamoxifen reduced breast cancer incidence by a third compared with women given placebo, the authors of the study caution that it is still too early to fully assess the risk-to-benefit ratio of tamoxifen as a preventative strategy for breast cancer.
Tamoxifen is well-known in its effect to decrease recurrence of (and death from) breast cancer; however, three clinical trials on the use of tamoxifen to prevent breast cancer have reported mixed results. The overall evidence supports a reduction in the risk of breast cancer, but whether this benefit outweighs the risks and side effects associated with tamoxifen is unclear.
Jack Cuzick from Cancer Research U.K., lead investigator of the International Breast Cancer Intervention Study (IBIS-I) and colleagues undertook a double-blind placebo-controlled randomized trial of tamoxifen, 20 mg/day for 5 years, in around 7000 women from the U.K., Europe, Australia and New Zealand who were aged 35-70 years and who were at an increased risk of breast cancer (e.g., they had a family history of the disease or had a benign lesion associated with an increased risk of breast cancer).
The frequency of breast cancer was reduced by a third among women given tamoxifen (69 breast cancers in 3578 women in the tamoxifen group and 101 breast cancers in 3566 in the placebo group). Endometrial cancer - considered to be increased by tamoxifen use - was doubled in the tamoxifen group (11 instances compared with 5 in the control group), but this increase was not statistically significant, and all cases were localized (stage I) and curable ...
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- Magazine article from: OB GYN News ZOLER, MITCHEL L. March 1, 2001 700+ words
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Tamoxifen and Breast Cancer Incidence Among Women with...mutations who developed breast cancer, 5 received tamoxifen and 3 got placebo. King...mutations who developed breast cancer, 3 got tamoxifen and 8 received placebo...
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- Magazine article from: OB/GYN Clinical Alert January 1, 2000 700+ words
...Feature Update on Tamoxifen- Associated Endometrial Cancer in Breast Cancer Patients By David...associated with tamoxifen therapy for breast cancer (OR = 1.52...487 women with breast cancer, 357 treated with tamoxifen and 130 controls...
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- Newspaper article from: Women's Health Letter Fuchs, Nan Kathryn April 1, 2001 700+ words
...a poor prognosis. Tamoxifen to prevent breast cancer A study using tamoxifen...women who developed breast cancer after taking tamoxifen would have tumors...between using 20 mg of tamoxifen to prevent breast cancer and using a placebo...
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- Magazine article from: Newsweek Begley, Sharon April 20, 1998 700+ words
...in the trial, tamoxifen reduced the incidence of breast cancer a full 45 percent...incidence of invasive breast cancer among women receiving tamoxifen--85 cases compared...did 85 women on tamoxifen still get breast cancer (and, in three...
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- Magazine article from: Internal Medicine O'Regan, Ruth Jordan, V. Craig September 1, 1999 700+ words
...preventive potential against breast cancer. Tamoxifen, the original selective...tamoxifen in the treatment of breast cancer? Tamoxifen was initially approved...incidence of contralateral breast cancer with tamoxifen use, with reductions...
