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Minimal change nephrotic syndrome associated with pneumococcal vaccine.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- Internists in Japan have reported the case of a woman who developed minimal change nephrotic syndrome shortly after receiving pneumococcal vaccination.
"A 67-year-old female was admitted to our hospital with eruption and cervical lymphadenopathy which occurred 1 week after pneumococcal vaccination," wrote Y. Kikuchi and colleagues, National Defense Medical College in Japan.
"Polyclonal hyperimmunoglobulinemia (IgG 6,620 mg/dl) and mild plasma cell proliferation (6.4%) in a bone marrow specimen were found, but a lymph node aspiration biopsy showed no specific findings. Normochromic and normocytic anemia with a positive direct Coombs test were also confirmed," they reported.
"Short-term intensive steroid therapy was given, but the systemic eruption and lymphadenopathy continued," Kikuchi and coworkers said. "About 4 months after vaccination, she suffered from edema in her face and legs and visual disturbance. When massive proteinuria (10.4 g/day) was found, she was admitted to our ward. A renal biopsy specimen showed a minor glomerular abnormality with mild interstitial plasmacytic infiltration. An ...
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