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New assay called ideal for epidemiologic studies.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- According to a study from Kenya, "Epidemiologic studies of pneumococcal pneumonia, including vaccine efficacy trials, are hampered by a lack of sensitive and specific diagnostic tests.
"Pneumococcal surface adhesin A (PsaA) is a genetically conserved, surface-expressed protein common to all serotypes of Streptococcus pneumoniae and is highly immunogenic," J.A.G. Scott and colleagues explained.
"Detection of anti-PsaA immunoglobulin G by recombinant PsaA enzyme-linked immunosorbent assay was evaluated for diagnosis of pneumococcal pneumonia in paired serum samples from 4 adult populations: 47 healthy control subjects, 56 clinic control subjects without pneumococcal disease syndromes, 109 patients with pneumococcal pneumonia, and 93 pneumonia patients with no evidence of pneumococcal etiology.
"By considering a twofold increase in antibody concentration as positive, sensitivity was 0.70, and specificity was 0.98," Scott's team reported. "With a 1.3-fold increase, these were 0.89 and 0.98, respectively. ...
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Source: HighBeam Research, New assay called ideal for epidemiologic studies.(Brief Article)