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Recent influenza A strains in Canada have evolved from two variants.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- Infectious disease researchers in Canada are delving into the evolutionary history of influenza strains in that country.
"Limited information is available concerning the molecular drift of the influenza neuraminidase (NA) genes," pointed out Y. Abed and colleagues, CHU Quebec, Infectious Diseases Research Center.
"We report on the genetic variability of the NA gene from 31 influenza A:H3N2 viruses isolated in the Province of Quebec (Canada) during the last three flu seasons (1997-2000).
"Amino acid substitutions within the NA protein were observed at rates of 1.01% and 0.45% between strains of the 1997-1998 and 1998-1999 seasons and between those of the 1998-1999 and 1999-2000 seasons, respectively. In most strains (28/ 31), amino acid changes occurred within at least one of four codons (197, 339, 370, and 401) previously implicated as antigenic sites."
"The 8 functional and 10 framework residues that compose the catalytic site of the NA enzyme were completely conserved over the study period. All isolates contained the seven conserved asparagine-linked glycosylation sites found in the NA of the progenitor A/Hong Kong/8/68 strain," Abed and associates reported. "In addition, most strains (30/31) had an eighth potential glycosylation site at position 329, whereas a ninth one was found at position 93 in 16 strains.
"The NA of all strains ...
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Source: HighBeam Research, Recent influenza A strains in Canada have evolved from two...