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Study emphasizes importance of genetic susceptibility to autoimmunity.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- Genetic background, rheumatologists report, plays an important role in susceptibility to autoimmunity.
"In previous studies we have established a link between cytomegalovirus (CMV) infection and an autoimmune response to the U1-70 k protein of the spliceosome in man. This autoimmune response, generally referred to as the anti-RNP (ribonucleoprotein) antibodies, is observed in about 30% of patients with systemic lupus erythematosus (SLE)," wrote J. Lipes and colleagues, Montreal General Hospital, in the journal Clinical and Experimental Immunology.
"We have also found that the CMV glycoprotein B (CMV gB) when expressed in a adenovirus vector (Ad) could induce a significant anti-U1-70 k antibody response in several strains of mice, such as C3H, MRL and BALB/c," the researchers reported.
"In the present study we examined the autoimmune response induced by immunization with Ad-gB in A/J and C57BL/6 (B6) mice and determined whether there was any autoimmune phenotype similar to that observed in patients with SLE. Thus groups of A/J and B6 mice were immunized with Ad/gB or with Ad alone and then observed for possible skin or kidney disease. In addition the autoantibody response to the spliceosome was measured, and the target antigens identified by immunoblot techniques."
Lipes' team reported: "All of the A/J mice mounted a very high ...
- Research sheds light on autoimmune response in diabetes.
- Newspaper article from: Immunotherapy Weekly February 18, 2004 700+ words
...agent or event that triggers this autoimmune response. Past research has suggested that...beta cells can contribute to the autoimmune response in diabetic patients and also play...and normal individuals cause an autoimmune response in diabetic patients, but no such...
- Autologous endothelium vaccination uses autoimmune response to halt colon...
- Newspaper article from: Vaccine Weekly March 17, 2004 700+ words
...NewsRx.net) -- Autologous endothelium vaccination uses autoimmune response to halt colon cancer. "Overcoming immune tolerance of...vaccination with autologous endothelium would induce an autoimmune response targeting tumor angiogenesis. To test this concept...
- Diabetes stopped before it starts. (autoimmune response is interrupted in mice)
- Magazine article from: Science News Pennisi, Elizabeth November 6, 1993 700+ words
...at Yale University. To tease out the trigger for this autoimmune response, both groups tested mice from birth onward for the development...old mice before the mice had developed any sign of an autoimmune response. In 75 percent of these mice, the GAD made peace, in...
- Structure allows autoantigenic epitopes to induce autoimmune response.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...autoantigenic epitopes to induce a widespread lupus-like autoimmune response. "A subset of lupus patients with severe nephritis and...autoantigenic epitopes to induce a widespread lupus-like autoimmune response. Proc Nat Acad Sci USA, 2004;101(10):3551-3556...
- Protein pieces halt autoimmune response. (Brief Article)
- Magazine article from: Science News August 14, 1993 700+ words
...this signal, a chemical called acetylcholine. Immune-system cells called T-cells play a key role in this autoimmune response. They break down acetylcholine-receptor proteins, creating two short fragments easily recognized by the immune...
- Autoimmune response can induce pancreatic tumor rejection.
- Newspaper article from: NewsRx Health September 27, 2009 700+ words
Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research. "There are extremely precise mechanistic methods augmenting the ability
- Autoimmune response to type II collagen clarified in MRL/Mp-lpr/lpr mice.
- Newspaper article from: Health & Medicine Week April 12, 2004 700+ words
2004 APR 12 - (NewsRx.com & NewsRx.net) -- Autoimmune anticollagen activity appears to play a key role in the pathogenesis of rheumatoid arthritis (RA). In a recent study from Japan, the "early phase of cartilage degeneration was immunohistochemically examined in order to clarify the importance
- Research reports on experimental immunology from Shanghai Jiao Tong University...
- Newspaper article from: Immunotherapy Weekly August 12, 2009 700+ words
...writing in the journal Clinical and Experimental Immunology report (see also Experimental Immunology). "However, as the archetype...published their study in Clinical and Experimental Immunology (Immunomodulatory drug FTY720...
Source: HighBeam Research, Study emphasizes importance of genetic susceptibility to...