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Wild-type measles strain responsible for SSPE outbreaks in New Guinea.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Genomic analysis revealed that outbreaks of subacute sclerosing panencephalitis (SSPE) in Papua, New Guinea, are caused by a wild-type measles virus, not the vaccine measles strain.
"A very high annual incidence of 56 per million population below the age of 20 years for subacute sclerosing panencephalitis (SSPE) has been reported from Papua New Guinea (PNG)," said Kenji Miki and colleagues working in Japan and New Guinea. "In a more recent study, we have confirmed this unusual high incidence for Eastern Highlands Province (EHP) of PNG."
The investigators found that the measles vaccination rate of EHP patients who developed SSPE was higher than for other infants in the province. Therefore, Miki and coworkers sequenced the hypervariable region of the N gene of 2 measles virus (MV) isolates from SSPE patients and 11 MV isolates from patients with acute measles. The entire H gene was sequenced for 2 of the 11 MV isolates from the measles patients.
Although different from previously reported MV nucleotide sequences - including vaccine strains - analyses revealed the cDNA of the 13 samples ...
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Source: HighBeam Research, Wild-type measles strain responsible for SSPE outbreaks in New...