AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Therapeutically effective dendritic cells generated by progenipoietin.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Progenipoietin (ProGP-4) stimulated the proliferation of dendritic cells that have shown effectiveness against cancerous tumors, according to a report in the International Journal of Cancer.
The chimeric molecule progenipoietin (ProGP-4) is a dual receptor agonist for the human FMS-like tyrosine kinase 3 (Flt3) and granulocyte-colony stimulating factor (G-CSF) receptors. Pia Bjorck and colleagues at the University of Pittsburgh and Pharmacia treated BALB/c mice subcutaneously with ProGP-4 (40-100 microgram/day).
The investigators found that the numbers of CD11c+ dendritic cells (DCs) and CD11c-/CD11b+ granulocytes increased significantly in the spleen, blood, and lymph nodes of ProGP-4-treated animals, reaching a peak on the seventh day of treatment. Approximately 8% of splenocytes were CD11c+ DCs, of which almost half could endocytose and present the fluorescent DQ-BSA antigen.
BALB/c mice with 7-day CMS4 sarcomas received two injections (1 week apart) of a vaccine containing either CD11c+ DCs alone or CD11c+ DCs pulsed with a specific murine tumor antigen (murine p53[subscript]232-240). Although the DCs alone did not significantly affect the tumors, the peptide-pulsed DCs caused shrinkage or a reduction in ...
- Therapeutically effective dendritic cells generated by progenipoietin.
- Newspaper article from: Cancer Weekly October 8, 2002 700+ words
...Progenipoietin (ProGP-4) stimulated the proliferation of dendritic cells that have shown...subcutaneously with ProGP-4 (40-100...numbers of CD11c+ dendritic cells (DCs) and CD11c...Progenipoietin (ProGP-4) generated increased numbers of dendritic cells (DCs) in ...
- Progenipoietin-1 increases plasmacytoid/myeloid dendritic cells in...
- Newspaper article from: Obesity, Fitness & Wellness Week July 31, 2004 700+ words
...there is a loss of dendritic cells (DC) in peripheral...progenipoietins (ProGP), a new family...cells, including dendritic cells, in the blood...treated with ProGP-1, developed...authors concluded, "ProGP-1 may be used...plasmacytoid and myeloid dendritic cells ...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Blood Weekly May 6, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- Dendritic cells heterogeneity and its role in cancer immunity.(Review Article)
- Magazine article from: Journal of Cancer Research and Therapeutics Kah-Wai, Lin Jacek, Tabarkiewicz Jacek, Rolinski April 1, 2006 700+ words
...Tabarkiewicz. Jacek, Rolinski. Jacek Dendritic cells are the most potent 'professional...primary immune response initiation. Dendritic cells originate from bone marrow progenitors...subsequently give rise to immature dendritic cells, which reside in peripheral tissues...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Nonprimed dendritic cells enhance immune response.(Brief Article)
- Newspaper article from: Vaccine Weekly June 19, 2002 700+ words
...writer - The addition of nonprimed dendritic cells to the same site targeted by the MUC1...researchers isolated activated nonprimed dendritic cells from syngeneic mice. Tumor growth...survival time was extended when the dendritic cells were simultaneously delivered to the...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
