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Schistosoma multivalent antigen reduces granuloma formation.(Brief Article)
2002 OCT 9 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A multivalent and a single antigen from the adult Schistosoma mansoni worm demonstrated an ability to stimulate a protective immune response in vivo, according to researchers in Brazil.
"Schistosome antigenic components are being tested as vaccine candidates with various degrees of success, but there are only few reports using multivalent antigens to stimulate an appropriate immune response that leads to resistance or granuloma modulation," commented Claudia S. Zouain and colleagues at the Universidade Federal de Minas Gerais in Brazil.
The investigators isolated peripheral blood mononuclear cells (PBMC) from patients with chronic intestinal schistosomiasis. The PBMCs were then exposed in vitro to PIII, a multivalent Schistosoma mansoni adult worm antigen, and to P24, a single antigen prepared from PIII (Human immune response in schistosomiasis: The role of P24 in the modulation of cellular reactivity to Schistosoma mansoni antigens. Human Immunology, 2002;63(8):647-656).
Both antigens significantly decreased cellular proliferation and granuloma formation and stimulated an increase in levels of interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-alpha). Exposure of P24 to polyacrylamide beads coated with S. mansoni antigens increased TNF-alpha levels over the in vitro ...
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