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NPS reports interim Preos carcinogenicity results.(Brief Article)
2002 OCT 3 - (NewsRx.com & NewsRx.net) -- NPS Pharmaceuticals, Inc., (NPSP) reported interim results from an ongoing 24-month preclinical carcinogenicity study with Preos, its proprietary drug candidate for treating osteoporosis.
A planned histopathological evaluation of a subset of rats confirmed that osteosarcoma has not yet been observed in study animals. The company cautioned that this interim result reflects 12 months of treatment with Preos and that final results will be available after the 24-month study is completed in 2003.
The absence of osteosarcomas after 12 months of dosing was expected based on previously reported studies using peptides related to PTH such as teriparatide or analogs of parathyroid hormone-related peptide (PTHrP). It should be noted that in the teriparatide study an increased incidence of osteosarcoma in rats was observed in the final 12 months of the study.
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- Newspaper article from: Pharma Marketletter October 3, 2005 700+ words
...demonstrate that treatment with PREOS (parathyroid hormone [rDNA origin] for injection...A New Drug Application for PREOS is currently under review by...the European equivalent to PREOS, which will be marketed in Europe...
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- Press release article from: PR Newswire September 20, 2003 700+ words
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...B round to fund clinical trials of its next-generation parathyroid hormone (PTH) analogue in four indications. Proceeds from the...based NPS Pharmaceuticals Inc.'s investigational product Preos, might show efficacy in fracture reduction, but they carry...
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- Magazine article from: Internal Medicine News Walsh, Nancy February 1, 2005 700+ words
...Intact human recombinant parathyroid hormone prevented both recurrent and...studies have shown that the parathyroid hormone (PTH) analog teriperatide...s proprietary formulation, Preos, was planned for February...
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- Magazine article from: Women's Health Weekly January 1, 2004 700+ words
...NewsRx.net) -- Local and systemic parathyroid hormone improves bone regeneration. According...research from the United States, "parathyroid hormone is one of the most promising therapeutic...the effects of combining systemic parathyroid hormone and a local parathyroid ...
- Emisphere Receives Patent Covering Oral Parathyroid Hormone Composition With...
- Press release article from: PR Newswire June 14, 2001 700+ words
...6,242,495 covering its oral parathyroid hormone (PTH) compositions and dosage...agent. A recombinant form of human parathyroid hormone (1-34), Forteo(TM) (teriparatide...delivery technology in combination with parathyroid hormone, will provide Emisphere and our...
- Excessive Parathyroid Hormone Disease.(Thyroid Disorders)
- The Columbia Univ. Coll. of Physicians & Surgeons Complete Home Medical Guide Holub, Donald A. Jacobs, Thomas January 1, 1995 700+ words
Excessive Parathyroid Hormone Disease Definition This is a condition in which too much parathyroid hormone is released. Because parathyroid hormone acts to keep calcium levels constant in body tissues, an overproduction (hyperparathyroidism...
- Parathyroid hormone gene therapy may stop osteoporosis in postmenopausal women.
- Newspaper article from: Gene Therapy Weekly January 22, 2004 700+ words
...com & NewsRx.net) -- Parathyroid hormone gene therapy may stop osteoporosis...Pth, with full-length human parathyroid hormone (prepro-hPTH) cDNA was constructed...electroporational gene transfer of parathyroid hormone might be a promising method to prevent...
