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Popular long-acting contraceptive linked to vascular dysfunction.(Brief Article)
2002 OCT 3 - (NewsRx.com & NewsRx.net) -- Long-term use of a contraceptive injected once every three months impairs the arteries' ability to contract and expand, possibly increasing the risk for heart disease, according to research reported in the September 3, 2002, rapid-access issue of Circulation: Journal of the American Heart Association.
Researchers studied depot medroxyprogesterone acetate (DMPA), commonly known by the brand name Depo-Provera. The drug affects the arteries' ability to "respond to different stimuli and particularly affects the ability of the artery to dilate," said senior author, Dudley J. Pennell, MD, a professor of cardiology at the Imperial College School of Medicine in London. Problems with arterial response can reduce blood flow, which can damage the heart.
DMPA had been considered a good drug for women who may have some cardiac risk factors such as smoking or high blood pressure or a family history of heart disease, Pennell said. But the new findings suggest that women with cardiovascular disease risk factors "would be wise to review that decision with their physician."
Pennell and colleagues measured vascular function in women who used DMPA for at least a year and compared the results to those of women who didn't use DMPA. They evaluated vascular function by measuring changes in the brachial artery using cardiovascular magnetic resonance imaging (CMR).
Twelve women taking DMPA and nine controls completed two brachial artery evaluations by CMR. Researchers evaluated ...
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Source: HighBeam Research, Popular long-acting contraceptive linked to vascular...