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Women with premature menopause at increased risk for potentially fatal adrenal condition.(Brief Article)
2002 OCT 3 - (NewsRx.com & NewsRx.net) -- Women with spontaneous premature ovarian failure (POF) are three hundred times more likely than members of the general population to develop a serious condition in which the body attacks the adrenal glands, according to a study by researchers at the National Institute of Child Health and Human Development (NICHD).
The study also reports that a test measuring immune system proteins known as antibodies is an effective way to diagnose the adrenal condition in women with spontaneous POF. The researchers published their findings in the August 2002 issue of Human Reproduction.
Premature ovarian failure occurs when the ovaries stop producing eggs and reproductive hormones well in advance of natural menopause. An estimated 1% of American women develop the condition by age 40.
Primary autoimmune adrenal insufficiency, also known as Addison disease, occurs when the body's own immune system makes antibodies that attack and destroy the adrenal glands. Antibodies ordinarily bind to disease-causing organisms, tagging them for later destruction by the immune system. The adrenal glands produce hormones (cortisol and aldosterone) that regulate salt metabolism and the body's response to stress. Addison disease is easily treated with medication that replaces the hormones that the adrenal glands are not making.
However, if a person with untreated adrenal insufficiency experiences a stressful event, like a severe illness, injury, or surgery, he or she can die from the condition. Despite the fact that adrenal insufficiency can be life-threatening, there has been ongoing debate in the medical community as how to best detect this condition in the early stages.
"This study shows that an adrenal antibody test is an effective way to determine if women with POF are at risk for primary autoimmune adrenal insufficiency," said Duane Alexander, MD, director of the NICHD.
The researchers, led by V.K. Bakalov, MD, a member of the developmental Endocrinology Branch at the NICHD, screened 123 women with POF for primary adrenal insufficiency. They used three different testing mechanisms to ...
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