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Lactobacilli may have potential for commercial in vivo immunotherapy.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- A study in rats suggests lactobacilli could play a part in vaccine delivery.
According to recent research from Sweden, "Lactobacilli have previously been used to deliver vaccine components for active immunization in vivo."
In their current work, C. Kruger and colleagues, Novum, Karolinska Institute, first expressed a streptococcal antigen in a lactobacillus.
"Vectors encoding a single-chain Fv (scFv) antibody fragment, which recognizes the streptococcal antigen I/II (SAI/II) adhesion molecule of Streptococcus mutans, were constructed and expressed in Lactobacillus zeae (American Type Culture Collection (ATCC) 393).
"The scFv antibody fragments secreted into the supernatant or expressed on the surface of the bacteria showed binding activity against SAI/II in enzyme-linked immunosorbent assay (ELISA), and surface scFv-expressing lactobacilli agglutinated SAI/II-expressing S. mutans in vitro without affecting the corresponding SAI/II knockout strain," reported Kruger and coworkers.
"Lactobacilli expressing the scFv fragment fused to an E-tag were visualized by scanning electron ...
- Maxygen Enters Into Development Program for Allergy Therapeutics With The...
- Press release article from: PR Newswire July 26, 2000 700+ words
...Maxygen (MAXY: Nasdaq) and the Karolinska Institute (Stockholm, Sweden) announced...common allergic conditions that the Karolinska Institute will help screen using sera and...of major seasonal allergies. The Karolinska Institute is a world leader in the area of...
- Karolinska Institute to Use OmniCorder's Functional Medical Imaging System;...
- Press release article from: Business Wire December 20, 2004 700+ words
...of its BioScanIR(R) System to Karolinska Institute in Stockholm, Sweden. The system...utility in patient management. "The Karolinska Institute's pilot program is the third in...disease are managed, and expect The Karolinska Institute's work will demonstrate this...
- Karolinska Institute Hosts Symposium on Medical Applications of Dynamic...
- Press release article from: Business Wire September 23, 2004 700+ words
...OMCT) today announced that the Karolinska Institute's Department of Oncology-Pathology...This is the first time that Karolinska Institute has organized a symposium on the...opportunity to collaborate with the Karolinska Institute on this symposium and look forward...
- ACADIA PharmacoGenomics and Karolinska Institute to Collaborate On Functional...
- Press release article from: PR Newswire April 7, 2000 700+ words
...ACADIA PharmacoGenomics and Karolinska Institute CMM announced today a collaboration...Center for Molecular Medicine at the Karolinska Institute and a Professor in the Department...samples and clinical data. ACADIA and Karolinska Institute will work together to analyze and...
- Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive...
- Press release article from: PR Newswire August 19, 2008 700+ words
...research collaboration with the Karolinska Institute, a leading European medical university...Ph.D., Professor at the Karolinska Institute, said, "The results from our...top healthcare priorities." The Karolinska Institute has completed a 38-subject Phase...
- INDIA'S BIOCON SIGNS MoU WITH SWEDEN'S KAROLINSKA INSTITUTE.
- News wire article from: AsiaPulse News June 2, 2005 700+ words
...of Understanding (MoU) with the Karolinska Institute in Sweden to collaborate in research...two organisations on May 27 at the Karolinska Institute, Sweden, between Kiran Mazumdar...Wallberg-Henriksson, President of Karolinska Institute, Biocon informed Bombay Stock Exchange...
- World-Renowned Karolinska Institute Adopts Pyrosequencing (TM) Technology For...
- Press release article from: PR Newswire October 5, 2000 700+ words
...departments at the world-renowned Karolinska Institute in Stockholm, Sweden have purchased...Professor of Medical Genetics from the Karolinska Institute at the Karolinska Hospital. "After...research institutions, such as the Karolinska Institute, the National Cancer Center, Tokyo...
- STERIS to Provide Third Detach(TM) System to Sweden's Karolinska Institute.
- Press release article from: PR Newswire May 17, 2000 700+ words
...provide a Detach automated system for Karolinska Institute's new Retzius Laboratory in Stockholm...approximately 16,000 mice. The Karolinska Institute has been using two other Detach...funded medical research in Sweden, Karolinska Institute's activities span a broad range...