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gag-based DNA vaccine effective in primates.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - An HIV DNA vaccine can produce sustained and effective cell-mediated immune responses to the virus in animals, researchers in the United States report.
Michael J. Caulfield and colleagues working at Merck Research Laboratories in West Point, Pennsylvania, evaluated several formulations of an HIV gag-based vaccine.
They found that several of the vaccine candidates tested elicited long-term antigen-specific cytotoxic T-cell activity, according to their report in the October 2002 edition of the Journal of Virology.
Caulfield and coauthors tested plasmid DNA vaccine based on codon-optimized sequences from the viral gag gene. The relative merits of including gag's tissue plasminogen activator leader sequence and/or a novel block copolymer adjuvent (CRL8623) were also assessed, they said.
All of the vaccine formulations produced cell-mediated antiviral immune responses in rhesus macaques for at least 18 months, study data showed. However, the version including the CRL8623 adjuvant induced superior cytotoxic T-cell activity after viral challenge.
The group of 23 immunized ...
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Source: HighBeam Research, gag-based DNA vaccine effective in primates.(Brief Article)