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DNA Vaccine vector induces IFN-alpha production in pigs.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- According to a study from Sweden, "The cytokine inducing capacity of the vaccine vector pcDNA3, a methylated form of the plasmid, and pcDNA3 encoding porcine interleukin (IL)-6 or granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in pigs, using a model with tissue chambers implanted subcutaneously.
"The production of interferon (IFN)-alpha, IFN-gamma, IL-6 and GM-CSF was studied at local (tissue chamber fluid (TCF)) and systemic (serum) levels during 3 days postinjection.
"All forms of the plasmid, except the methylated, induced a transient local production of IFN-alpha but no plasmid-induced production of IFN-gamma, GM-CSF or IL-6 could be detected after injection of the plasmids," reported E. Johansson and colleagues.
"The IFN-alpha response increased markedly at repeated injections of pcDNA3. ...
- DNA Vaccine vector induces IFN-alpha production in pigs.
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