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Standard vaccine offers long-term immunity.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- Scientists at the University of North Carolina at Chapel Hill have found evidence indicating that the standard vaccine against smallpox confers long-term immunity.
Writing in the New England Journal of Medicine, Dr. Jeffrey A. Frelinger, Kenan professor and chairman of microbiology and immunology in the School of Medicine, and postdoctoral researcher Dr. Lawal Garba said despite substantial interest today "in the durability of immune responses following smallpox vaccination," little direct or quantifiable evidence of such durability exists.
"It's a question that's been largely unexamined," said Frelinger, who mentioned reports suggesting that the standard vaccine, which contains live vaccinia virus but not smallpox, or variola, virus, could protect against lethal infection in people vaccinated 50 years previously.
Vaccinia vaccine triggers an immune response to orthopoxviruses that can infect humans, such as monkeypox, cowpox, vaccinia and variola.
During the course of another investigation, Frelinger and Garba tested blood samples from 13 laboratory workers who had been vaccinated according to federal guidelines because they work with vaccinia virus. Four had been vaccinated fewer than five years ago. Another nine individuals had been vaccinated either between 5 and 35 years previously or more than 35 years ago.
The researchers tested the strength of each individual's CD8 T cell response to vaccinia exposure by counting the number of cells that respond to vaccinia by production of interferon-gamma.
In the body's cellular immune response, CD8 T cells are a type of cytotoxic T lymphocyte, or CTL, white cells that kill other body cells that have been infected by ...
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...accelerating disease," wrote J.A Frelinger and colleagues, University of North...ameliorating the disease process." Frelinger and colleagues published their study...additional information, contact J.A. Frelinger, University of North Carolina, Dept...
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...suspended by honorary chief Jerry Enick last fall. Sharon Frelinger, who was ousted, said the sitting tribal government is illegal...toppled from office and later banished. "It was a coup," Frelinger said. "I feel like they are not the legal government, and...
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...any post-aspirin platelet function test," wrote A.L. Frelinger and colleagues, University of Massachusetts. The researchers...aspirin resistance defined by other commonly used assays." Frelinger and colleagues published their study in the Journal of Thrombosis...
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- Newspaper article from: Sarasota Herald Tribune June 29, 2000 700+ words
...donations may be made to Hospice of Southwest Florida, 5955 Rand Blvd., Sarasota, FL 34238. Edith H. Frelinger Edith H. Frelinger, 91, Sarasota, died June 26, 2000. She was born March 18, 1909, in Waukegan, Ill., and came to Sarasota...
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...Ronald Swanstrom, professor of biochemistry and biophysics and director of the UNC Center for AIDS Research; Dr. Jeffrey Frelinger, professor and chair of microbiology and immunology at UNC; and Drs. David Montefiore of Duke University and Phil Johnson...
Source: HighBeam Research, Standard vaccine offers long-term immunity.(Brief Article)