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Multiantigen vaccine effective against malaria in rhesus macaques.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Rhesus macaques were protected against a lethal Plasmodium knowlesi infection by immunization with a vaccine composed of cytokines and DNA plasmids expressing P. knowlesi antigens, and boosting with engineered vaccinia virus expressing the same antigens.
William O. Rogers, and colleagues in the U.S. military and at Virogenetics Corporation and the National Institutes of Health (NIH), primed 11 rhesus macaques with a vaccine formulated with granulocyte-macrophage colony-stimulating factor, interleukin-4, tumor necrosis factor alpha, and DNA plasmids that expressed two preerythrocytic-stage proteins and two erythrocytic-stage proteins. Attenuated vaccinia virus strains expressing the same four antigenic proteins were used as boosting immunizations. Four unimmunized animals acted as controls.
Antibody titers against sporozoites (160-8,096) and infected erythrocytes (1,810-5120) were evident 2 weeks after boosting in the treated animals. Geometric mean titers of antibodies against P. knowlesi circumsporozoite protein (PkCSP) were 1,761-24,242.
Incubation of peripheral blood mononuclear cells (PBMC) from vaccinated macaques with PkCSP peptides stimulated the release of gamma interferon (Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen. Infection and Immunity, 2002;70(8):4329-4335).
The immunization schedule successfully protected nine of the macaques against a potentially lethal challenge of 100 P. knowlesi sporozoites. Two ...
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Source: HighBeam Research, Multiantigen vaccine effective against malaria in rhesus...