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Murine aerosol challenge model provides correlation between antibody response and protection.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A group from the Dana Farber Cancer Institute and Harvard Medical School in Boston used the murine aerosol challenge model to demonstrate a correlation between level of antipertussis toxin antibodies and protection against severe pertussis disease.
"Serum antibodies to pertussis toxin (PT) have been shown to be protective against severe pertussis disease, although a specific level of anti-PT antibody that correlates with protection has not been demonstrated," explained Jon B. Bruss and George R. Sieber. "Current animal models such as the intracerebral challenge model have significant limitations in correlating protection to a specific level of anti-PT antibody."
Bruss and Sieber primed 6-day-old BALB/c mice with tetranitromethane-inactivated pertussis toxin (PTx) to determine the level at which they were protected against aerosol challenge with Bordetella pertussis. Responders were defined as those mice that developed levels of anti-PT IgG antibodies of at least 1 microgram/mL.
Responder mice were evident on the day of aerosol challenge. These animals demonstrated an ability to double the levels of anti-PT antibodies by the seventh day postchallenge and to increase levels of anti-PT IgG by an order of magnitude within 2 weeks after the aerosol challenge.
The responder mice experienced less leukocytosis, smaller weight loss, and reduced pulmonary proliferation of B. ...
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