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Cholera toxin offers some protection against H. pylori infection.(Brief Article)
2002 OCT 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Researchers in Sweden found that mmunization of mice with the cholera toxic (CT) did not protect against Helicobacter pylori infection, but did decrease bacterial load after infection without causing severe gastritis.
"Therapeutic vaccination is an attractive strategy to control infection and disease caused by Helicobacter pylori," said S. Raghaven and colleagues at Goteborg University in Sweden.
The investigators immunized mice with a vaccine composed of H. pylori lysate and the mucosal cholera toxin as an adjuvant. Although the vaccine did offer some protection against initial infection and a reinfection challenge, it stimulated an inflammatory response leading to severe gastritis.
When Raghaven and associates treated mice with an oral dose of the CT adjuvant alone, H. pylori infection was not prevented, but reinfection bacterial load was 20 times lower and gastritis did not develop.
In vitro studies revealed that H. pylori antigens stimulated a proliferative response of mononuclear cells from animals immunized with the lysate and CT adjuvant and from animals given only the CT. However, only animals that received the lysate and CT vaccine mounted a significant specific anti-H. pylori antibody response (IgG1 and IgG2a) against H. pylori antigens.
. "The results illustrate the complex balance between protection and harmful inflammation after postinfection vaccination against H. pylori as studied in a mouse model," concluded ...
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