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Nucleocapsid proteins protect against hantavirus.(Brief Article)
2002 SEP 25 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Nucleocapsid proteins from two hantavirus strains conferred complete protection against hantavirus challenge in voles, according to a report in the Journal of Virology.
"Hantaviruses are rodent-borne agents that cause hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome in humans," explained Cristina de Carvalho Nicacio and her colleagues in Sweden, Argentina, and Finland. "The nucleocapsid protein (N) is relatively conserved among hantaviruses and highly immunogenic in both laboratory animals and humans, and it has been shown to induce efficient protective immunity in animal models."
The researchers investigated the ability of recombinant nucleocapsid proteins (rN) from the Puumala (PUUV), Topografov (TOPV), Andes (ANDV), and Dobrava (DOBV) hantavirus strains to provide cross-protection in bank voles. After inoculation, the voles were challenged with PUUV (Cross-protection against challenge with Puumala virus after immunization with nucleocapsid proteins from different hantaviruses. Journal of Virology, 2002;76(13):6669-6677).
Complete protection was conferred on the voles that were inoculated with PUUV or TOPV rN. DOBV protected 7 out of 10 voles. In contrast, ADNV rN inoculation prevented infection in only 3 out of 8 animals, despite being more closely related to PUUV rN than DOBV rN.
Antibody production indicating cross-protection was highest in animals immunized with ANDV rN, followed by those inoculated with TOPV rN. ...
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Source: HighBeam Research, Nucleocapsid proteins protect against hantavirus.(Brief Article)